The integration of culture and tourism is an important way to improve the efficiency of culture and tourism development. The Guangdong-Hong Kong-Macao Greater Bay Area continues to accelerate the development process of the integration of culture and tourism，and has obtained many achievements in the integration of concepts，resources，markets，and industries of culture and tourism. However，at the same time，it is also facing challenges such as insufficient innovation drive，limited technological empowerment，and insufficient market response. It is necessary to strengthen innovation-driven development，market dynamics research，technological empowerment and institutional mechanism construction to promote high-quality development of the integration of culture and tourism in the Guangdong-Hong Kong-Macao Greater Bay Area.