After the global financial crisis in 2008，the world's main economies began to re-examine the drawbacks of systemic risk and micro prudential supervision，and take the important transformation based on macro prudential supervision.At present，the new financial formats develop rapidly，and has greatly expanded the tentacles and operation boundaries of financial system，and at the same time，it also makes China's systemic financial risk management face greater challenges.China's economy has entered a period of high financial risk.However，the current segregation supervision model is faced with many challenges，like severe challenges brought by the transformation of the financial separation business pattern to the mixed operation pattern.Drawing lessons from the experience of policy reform in macro Prudential Management of the developed countries，it is an important way to prevent and resolve systemic financial risks by thoroughly analyzing the difficulties in the supervision of separate supervision system in China.