International cooperation in the field of science and technology innovation is a key in advancing the Belt and Road Initiative in the new era，starting a new pattern of all-round opening up and realizing the goal of national rejuvenation. Developing the ability of innovation governance，building a backbone network for innovation，strengthening the support of innovative information and enhancing the effectiveness of international cooperation in science and technology are the main starting points for scientific and technological cooperation under the framework of the Belt and Road Initiative.