Confronting with the global financial crisis，getting out of the dilemma is of paramount importance for the small and medium-sized enterprises. Furthermore，whether they could survive and progress in the competition，lies on their capacity of generating and utilizing knowledge. Consequently，the small and medium-sized enterprises have to take advantage of their own strong points，seize every opportunity，practice the managing equality，establish knowledge management structure，and achieve the goal of knowledge innovation. After realizing the above aspects，they are sure to get through the crisis and the promising future is waiting for them.