Twin cities have been the major type of urban communication. However，the new economic partnership signed by Chicago and Mexico launches a series of initiative in trade，innovation，education and other fields and，promotes employment and competitiveness in advanced industries. The world is evolving as a network of trading cities，seamlessly integrating the exchange of people，goods，services，energy，capital，ideas，and culture. North America as a unique competitive producing and trading platform has been driven by cities and metro regions which in turn become the engine and center for trading and investment. The partnership of Chicago and Mexico city has implications for Chinese cities in following aspects：（1）integrated economic trading relationship between twin cities；（2）proper economic trading in conform to industries and development，sharing innovative policy and enhancing competitiveness；and，（3）deepened cooperation in innovation，education and human capital.