Ukraine crisis happened in 2014 was one of the most important international issues which made great impact on the international pattern，regional situation and relations between the big powers. The region of Central Asian and Ukraine，situated in the same area of Europe and Asia，have close relations. The Ukraine crisis has exercised direct influence over the region of Central Asia，particularly to the Russian economic crisis which led to a perceptible decline of economic development in Central Asian countries. The Ukraine crisis has deteriorated the relations between Russia and the West. Although Central Asian countries stood neutral in Ukraine issue and wouldn’t like to offend any party，this would make “their bread buttered on both sides” more difficult of the multilateral diplomacy between Russia and the West by the Central Asian countries. Through the Ukraine crisis，the Central Asian countries were aware that “the color revolution” would not only overthrow their regime，toppled down their governments but split up their countries and would even lead to a war. All countries would draw lessons from this issue and focus on maintaining social and political stability.