Guangzhou high-tech Zone should use the way of innovation driven to achieve the reorientation under the economic globalization. This paper analyzes the development performance and evolution trajectory of China's high-tech zones, and explorers the development course, stage of development and opportunities for development of Guangzhou High-tech Zone, and studies the innovation development orientation of Guangzhou High-tech Zone. On this basis, this paper proposes innovation carriers and public policy system aiming at promoting the development of Guangzhou High-tech Zone.