The trend that the United States and Japan to led Trans-Pacific Partnership Agreement（TPP）negotiation process has becoming increasingly apparent after Japan’s accession. The extent and speed of compromise from both sides driven by same and similar strategic interests is now the key whether an agreement of TPP can be reached or，at what time，to be reached. Under the rapidly changing strategic situation in East Asia as background，correspond of U.S. -Japan bilateral strategic interest is very considerable. This is why the two countries have joined TPP，and listed it as the primary cause of the country in the area of economic integration arrangements in the various priority options. Meanwhile，the United States and Japan failed to reach agreement on TPP in the short term，though compromise over specific terms，reflects significant strategic differences between the two sides：in terms of strategic configuration，strategic urgency，domestic situation and economic relations，there are significant differences between the two countries.