As the core agglomeration area of China’s artificial intelligence industry，the Guangdong-Hong Kong-Macao Greater Bay Area has prominent advantages in technology research and development，enterprise clusters and policy support. However，it still faces multiple bottlenecks in building a globally competitive artificial intelligence innovation highland. Insufficient technological innovation capabilities are manifested as reliance on chips，shortcomings in algorithms，and data bottlenecks. The shortage of high-end compound talents restricts the upgrading of industries. The conflict between data sharing and privacy protection is becoming increasingly prominent，and the utilization rate of data resources is low. The insufficient development of regional collaboration，the differences in cross-regional policies and regulations，and the complexity of cross-border collaboration have hindered the flow of essential elements. Application scenarios are difficult to implement. Looking ahead，we need to focus on five aspects：First，break through the bottleneck of technology，build an independent and controllable artificial intelligence technology system，strengthen technological innovation in the field of artificial intelligence，and enhance the capacity for independent research and development；Second，optimize talent strategies and build a high-level global artificial intelligence talent base；Third，improve the governance system and balance innovation and risk management and control；Fourth，deepen regional collaboration and build a “Guangdong-Hong Kong-Macao Artificial Intelligence Community”；Fifth，promote the implementation and commercialization of application scenarios in the field of artificial intelligence.