Against the backdrop of globalization and regional economic integration，as a major foreign trade province in China，Guangdong has seen its trade relations with other RCEP countries deepen increasingly. In recent years，trade between Guangdong and other RCEP countries has shown a favorable trend of steady growth and deepened cooperation. The trade structure has been continuously optimized，and the market distribution has diversified. Among them，cross-border e-commerce has become a new highlight. Meanwhile，the index analysis results show that Guangdong has demonstrated a differentiated competitive layout in bilateral trade with other RCEP countries，and its trade structure has certain stability and flexibility. The trade complementarity of some products has been adjusted in different years. Further analysis reveals that issues such as underexploitation of trade potential，insufficient policy coordination，limitations in industrial cooperation，and bottlenecks in logistics and transaction operations have hindered the further development of trade between Guangdong and other RCEP countries. Therefore，Guangdong should deepen economic and trade cooperation and activate trade potential，strengthen the construction of policy coordination and cooperation mechanisms，deepen industrial cooperation and elevate the level of cooperation，enhance the efficiency of logistics and supply chains.