In 2024-2025，Europe is at a crucial diplomatic juncture due to the geopolitical crisis of the Russia-Ukraine conflict and the US presidential election. Macron proposed “strategic wake-up”，calling on Europe to get rid of its strategic dependence on the US and enhance its national defense and economic strength. The President of the European Commission announced the “Re Arm Europe” plan，taking steps towards strategic autonomy. In the field of EU-US relations，under the impact of “Trump 2.0”，old issues such as tariff wars and US exit the Paris Agreement between the US and Europe have re-emerged，and new contradictions such as the competition for the discourse power of values have been added. The shift of the US strategic focus，political polarization，and Trump’s closeness to Putin have caused the transatlantic relationship to split，and Europe has begun to wake up and reduce its dependence on the US. The EU-Russia relationship presents a “double track”，with differences in the policies towards Russia between the mainstream of the EU and some member states，as well as different political forces. Geopolitical games have intensified. The EU competes with Russia in many aspects，and Europe is difficult to get rid of its energy dependence on Russia. The future direction of the EU-Russia relationship is affected by issues such as the Ukraine issue. The EU-Japan relationship has continued to solidify，with enhanced military cooperation and prominent economic security issues. The “double transformation” process has been steadily advanced，and the two sides have deepened cooperation in many fields. However，it also faces challenges such as differences in strategic focus，and the cooperation has a tendency to target third countries.