Under the influence of the Russia-Ukraine conflict and the evolution of the global strategic pattern，in addition to cooperation and coordination in dealing with Russia and China，a new clue with “control” and “autonomy” as the main characteristics of the U.S.-EU relationship may clearly turn out. Based on an identity recognition of “spire class”，the geographical buffer of important regions，and the huge economically developed market，the strategy of the United States toward Europe has formed a target range consisting of “thoroughly controlling Europe and making it act in full accordance with the interests of the United States” and “influencing Europe’s collective decision-making to a greater extent in various important fields and issues，and easily preventing Europe from harming US interests”. The United States has taken comprehensive measures，including continuing to encroach on EU functions with NATO；taking advantage of the Russia-Ukraine conflict，setting military deployments in Europe，including stationing nuclear forces；comprehensively intensifying the disguised economic plunder of Europe；promoting NATO to fight with China. In response，Europe has taken measures to pursue strategic autonomy，such as comprehensively building its security capabilities，vigorously promoting the development of the digital economy，actively increasing the level of energy reserves，and highlighting Europe’s unique values. This game of “control” and “autonomy” has had multiple impacts on the United States，Europe，the western camp，and the global strategic landscape.