Under the background of the vigorous development of cross-border e-commerce，the enterprises of traditional industrial zone directly connect with global consumers through cross-border e-commerce，which is not only an inevitable choice to comply with the trend of the times，but also an important opportunity to enhance their competitiveness and expand the international market. On the basis of sorting out the current situation of the enterprises going overseas in cross-border e-commerce industry zone，the report deeply analyzes many difficulties faced by the traditional enterprises of industrial zone in the process of transforming to cross-border e-commerce，involving several key areas such as the thinking mode，the production mode，the talent pool，the capital investment，the brand building and supply chain collaboration. It is from six aspects of the thinking innovation，the production reconstruction，the talent cultivation，the cost investment planning，the transformation of brand strategy，the ecological optimization to propose the way to break the deadlock，helping the enterprises of industrial zone to achieve the goal of “selling globally”.