The report focuses on the globalization layout of cross-border e-commerce industrial chain and supply chain，and deeply analyzes its development trend in the context of global trade pattern reshaping. Under the tide of globalization，cross-border e-commerce presents three major development trends，such as the growth of global market scale，the diversification of regional pattern，and China’s strength appearing increasingly. Meanwhile，cross-border e-commerce faces opportunities such as the market potential，the technological progress，the policy support，and the supply chain advantages in the process of globalization，as well as challenges such as the international trade policies，the supply chain coordination，and the market competition. In the face of a complex international environment，enterprises must enhance their capabilities in the technology empowerment，the market cultivation，the compliance management and the brand building to improve their international competitiveness，and make forward-looking plans in the technological innovation，the market expansion and the industrial synergy.