As an advanced form of productivity characterized by technological innovation and high-quality development，the new quality productive forces promotes cross-border e-commerce to achieve qualitative leaps in business models，supply chain management and service experience through technological innovation，factor innovation and industrial innovation，injecting strong momentum into the development of the industry，and becoming an important force to promote and reshape the new pattern of global trade. The report elaborates the development status of cross-border e-commerce and the integration of cross-border e-commerce and the new quality productive forces，and analyzes the challenges faced by the development of cross-border e-commerce under the guidance of the new quality productive forces，including the potential risks in the early stages of new technology application，the systemic risks caused by policy uncertainty，the profit compression caused by disorderly competition，the rising costs caused by intellectual property disputes，the increased regulatory difficulties caused by information barriers，and the internal resource consumption caused by policy competition. It put forward targeted countermeasures and suggestions by strengthening industry supervision，enriching AI technology supply，promoting high-quality development of overseas warehouses，exploring cross-border data asset capitalization，and optimizing industrial top-level design.