With the spread of the global COVID-19 epidemic，the epidemic situation in Southeast Asia has experienced twists and turns. Countries have roughly experienced three waves of COVID-19，but different countries have differences. In the face of the changes in the COVID-19 in the past three years，Southeast Asian countries timely implemented and adjusted their prevention and control policies according to their respective epidemic situation and national conditions. From strict epidemic prevention and control measures in the early stage of the epidemic to the late stage，they chose to shift from “virus clearance” to “coexistence with viruses” policy，supplemented by economic and social policies and regional anti epidemic cooperation. The COVID-19 has lasted for three years，which has had a serious impact on the economic and social development of Southeast Asian countries，and will also have a profound impact on the development of the region in the medium term. It has delayed countries to achieve the medium-term development goals，slowed down industrial transformation and upgrading，led to the rise of poverty rates in some countries，restricted the free flow of regional production factors，and thus affected the development process of the region to a certain extent.