The deep integration of industry，academia，and research is the core content and important manifestation of innovation-driven development. Strengthening the role of corporate innovation entities，enhancing their leadership position，and promoting the deep integration of industry，academia，and research have become pivotal steps. This advancement propels the establishment of a synergistic innovation ecosystem led by enterprises，contributing significantly to the acceleration of Beijing’s international science and technology innovation center. Taking Beijing Chaoyan Pharmaceutical Research Center Co.，Ltd. as a case study，this report delves into its experiences in leading industry-academia-research collaboration. The center has primarily established a comprehensive platform for innovative drug development services. It has forged long-term partnerships with universities，institutes，industrial alliances，etc.，facilitating activities such as talent exchange，technological breakthroughs，and market research. These collaborations effectively ensure the synergy of industry，academia，and research in activities related to talent cultivation，technological innovation，and collaborative industry efforts. Promoting enterprise-led collaborative innovation among industry，academia，and research involves several key factors. Firstly，it requires exploring novel models for organizing core technological breakthroughs，strengthening top-level designs for pivotal technology innovation systems. Secondly，it necessitates a focus on national strategies and significant industrial demands，refining mechanisms for leading technology enterprises to participate in major national scientific and technological tasks. Thirdly，it emphasizes the role of technology companies in leading the construction of innovative platforms for substantial core technology break-throughs. Fourthly，it underscores elevating the status of enterprises as primary forces in technological innovation，leveraging leading technology enterprises as key drivers. Lastly，it encourages active engagement of small and medium-sized enterprises in collaborative innovation between industry，academia，and research，augmenting safeguard mechanisms for technology enterprise-led collaborative innovation.