The cooperative development of cultural industries in the Guangdong-Hong Kong-Macao Greater Bay Area is of great significance for building a new development pattern and realizing a virtuous circle of the national economy. The cultural industry cooperation projects and platforms in the Guangdong-Hong Kong-Macao Greater Bay Area have gradually increased，and great achievements have been made in the development of industrial cooperation. At the same time，the Greater Bay Area is also facing many challenges，such as institutional obstacles，the revival of Lingnan characteristics，and unbalanced development. The Hong Kong-Macao Greater Bay Area has a solid foundation for the cooperative development of cultural industries. Under the new development pattern，the Guangdong-Hong Kong-Macao Greater Bay Area should give full play to the comparative advantages of the three places and take the road of coordinated development of the cultural industry. The Bay Area should focus on collaboration of five areas，including digital content，park construction，Lingnan culture，exhibition planning，and cultural tourism，to jointly build a world cultural industry innovation center.