Regime change become the principal policy of The Trump’s Adm-inistrations’ to Iran once again after a few decades. Stigmatization of Iran，support of the Iranian opposition，oil embargo，the build-up of regional anti-Iranian coalition are the major measures of the President Trump’s regime change. The United States aimed to seek for the internal collapse by accelerating the pressure to Iran. Although Iranian President Hassan Rohani is pushing Anti-Money Laundering Law to promote trade facilitation and renew the economy，Iran hasn’t raised the resistence against American pressure to the strategic height. While China，Russia and the European Union could not form an effective international alliance against the United States，Therefore，it’s difficult for Iran to truly guard against US sanctions and regime change policy. It will be a high probability event that Iran becomes weak in the future，and Iran will be the victim of the US reconstruction of the Middle East security structure.