In the context of continued trade tensions，weak demand，and indefinite geopolitical risk between the world’s major economies，cross-border e-commerce has been a major highlight in China’s foreign trade in recent years. More and more enterprises want to join the team of “e-commerce going overseas”. However，Cross-border e-commerce enterprises meet the significant compliance challenges in operations when face the differences in regulations，policies，and culture between different countries and regions. The report provides a practical and feasible compliance management methodology for cross-border e-commerce enterprises. By analyzing relevant data and real cases，it explains the eight compliance risks of “commodity going overseas” and the six compliance risks of “capital going overseas”，and then gives suggestions on compliance risk prevention and compliance system construction. Under the premise of “knowing，understanding and following the rules”，cross-border e-commerce enterprises can better adapt to and successfully carry out overseas operations through effective compliance management，and achieve long-term competitive advantages in the fiercely competitive international market.