The Silk Road was a major channel of commercial trade and cultural exchange among the ancient foreign countries and China. With the continuous development of business intercourse and cultural communication，the extraterritorial medical knowledge and medicines have also entered into China，which have an important impact on the development of Chinese medicine. The storax was widely used in the life of the China after it was introduced from the Silk Road in the Qin and Han Dynasties. It was later used as medicine by Chinese physicians. Although its means，dosage and treatment have already undergone changes，it is still the central component of Shexiang Baoxin Pill，which is an independent intellectual property medicine in China. This paper reveals the important role of the Silk Road in the cultural exchange of Chinese and foreign medicine and its positive influence on the development of Chinese medicine through a detailed review and elaboration of the evolution history of Storax in Chinese medicine.