Since China’s reform and opening up，Guangzhou has Always been always been one of the pioneers in opening up. Guangzhou’s foreign trade system has successively gone through decentralization of foreign trade management power，contractual management responsibility system，transformation of enterprise management mechanism，exchange rate merger，docking WTO rules，liberalization of foreign trade management power，etc. The investment management system in Guangzhou has led to the development of two-way investment through investment promotion，industrial transfer strategy，the “admittance negative list” rule of utilizing foreign capital，foreign investment and “one belt and one road” construction. In the new era of comprehensive opening up，Guangzhou’s opening up process and experience have important practical significance. The trend of opening up in the future is to focus on the construction of “one belt and one road”，adhere to the principle of “bringing in and going out”，abide by the principle of co construction and sharing，strengthen the opening and cooperation of innovation capability，and promote the gradual formation of the open pattern of China’s internal and external linkage，and the mutual benefit between East and West.