In the face of the opportunities and challenges of the fourth industrial revolution and the vigorous development of China’s manufacturing industry，Zhejiang Province，based on its own development advantages，has moved from “Made in Zhejiang” to “Made in Zhejiang” under the guidance of the “Eighth Five-Year Plan”，vigorously developing the digital transformation of manufacturing industry，and has achieved good results. In general，the province promotes industrial empowerment with digital economy，takes the development of intelligent manufacturing as the key point，takes digital empowerment as the decisive point，highlights the advantages of reconstruction，reshapes the manufacturing industry pattern，and leads the new paradigm of industrial innovation with digital technology. This study combs the typical cases of manufacturing digitalization in Zhejiang Province，and analyzes the results of the current digitalization practice in Zhejiang Province. The main conclusions are as follows：Zhejiang Province vigorously develops digital manufacturing，the new intelligent manufacturing group continues to grow，the core industry of digital economy has a strong growth momentum，and the industrial digitalization has increased efficiency. The digital transformation has injected tremendous vitality into the future of Zhejiang’s manufacturing industry. In the process of transformation and development，it is also necessary to face up to and pay attention to the common problems that may occur，actively solve them，and accelerate the digital transformation.