It has become the only way for manufacturing enterprises to enhance their competitiveness by empowering enterprises with digital innovation through emerging digital technologies such as big data，cloud computing，internet of things，blockchain and artificial intelligence. Scientific measurement of the digital innovation level of manufacturing enterprises is the basis of the subsequent theoretical research，but also the necessary requirement of the digital development of manufacturing enterprises. Based on the theory of innovation value chain，this report constructs an evaluation system for the digital innovation level of manufacturing enterprises. Using the data of listed manufacturing enterprises in China，entropy method and Moran，I are used to measure the digital innovation level of manufacturing enterprises and study the spatial correlation. The results show that：computer，communications and other electronic equipment manufacturing leads other industries by industry ranking；in terms of the ranking of provinces and cities，Beijing，Guangdong and Shanghai are ahead of other provinces and cities；in terms of spatial correlation，the test results of the global Moran’s I show that the digital innovation level of manufacturing in Chinese provinces and cities is significantly positively correlated from 2016 to 2020，but not in 2021. The results of local Moran，I test show that，among the manufacturing digital innovation levels of Chinese provinces and cities，Beijing，Tianjin and Guangdong present high-high agglomeration；Jiangxi province presents low-high agglomeration；Inner Mongolia，Xinjiang，Yunnan and Tibet showed low-low agglomeration. Heilongjiang and Sichuan provinces showed high-low agglomeration. This report provides theoretical basis and reference value for measuring the digital innovation level of manufacturing enterprises，and provides relevant enlightenment for better driving the digital innovation of manufacturing enterprises. Based on the research results，this report puts forward the following policy recommendations：strengthening the digitization of innovation factors and building a digital innovation ecosystem；strengthen the development and application of digital technology；we will give full play to the radiating effect of advantageous regions and improve the spatial balance of regional digital innovation.