Since 2023，the U.S. economic policy toward China has begun to shift from “decoupling” to “de-risking” and has formed an obvious strategic consensus and policy convergence with its European and Asia-Pacific allies at the cognitive and operational levels. The logic of the U.S. strategic transformation toward China is based on three considerations，namely，the re-consolidation of its alliance partner system，the re-weighing of its own interests，and the re-understanding of the strategic competition between China and the U.S. Overall，the U.S. “de-risking” policy toward China has had a greater negative impact on the world economy and China’s development，manifesting itself in further exacerbating the fragmentation of the global economy，accelerating the downward spiral trend of China-U.S. strategic competition，and hindering China’s climbing up in the global value chain. In this regard，China should maintain its strategic focus，work intensively in key technological fields，and establish an independent and controllable science and technology system；China should actively participate in the process of reshaping the “de-risking” discourse narrative and replaces the so-called “China risk” with global risks as the core connotation of “de-risking”；China should accelerate the construction of a new development pattern and realize a diversified layout of the supply chain.