Relying on advanced technologies such as big data and artificial intelligence to enhance urban governance capabilities is a crucial lever for modernizing the governance system and its overall effectiveness. The Nanjing 12345 government hotline has harnessed its data advantages and initiated four major endeavors focused on megacity governance. Firstly，it empowers interaction between the government and the public to streamline and optimize channels for expressing people’s demands. Secondly，it supports urban development and contributes to the creation of a model city that meets citizens’ expectations. Thirdly，it facilitates the formulation of urban planning and enhances the efficiency of public services during the 14th Five-Year Plan period. Lastly，it strengthens crisis response capabilities to ensure people’s well-being during emergencies. Starting with digitalization and intelligence，Nanjing continuously explores innovative approaches to empower urban governance and contribute to the development of megacities.