The international community including China’s neighboring countries was influenced by the continuing COVID-19 pandemic and other public health security crises in 2022. Although the global pandemic has become preventable due to the prevalence of COVID-19 vaccine，the variating strains and the uneven distribution of vaccine still increased the difficulties of work. Under this circumstance，cooperation seems especially important. Under several guiding principles，China and global community including China’s neighboring countries has been taking cooperative actions to prevent the COVID-19 pandemic，taking pharmacal intervention，balancing targeted routine COVID-19 protocols and emergency measures，ensuring both epidemic control and socio-economic development. Furthermore，China and global community including China’s neighboring countries has also been taking cooperative actions in building the Global Community of Health for All and improving the global public health governance system through cooperation in epidemic prevention and control.