This paper is using the documents of Qing dynasty and English literature of 19th century to research the key channel of Tibetan central region and other Himalayas Region. Such as Sikkim，Bhutan，and Nepal，to discuss the road，village names，mountain names，river’s names，and trade routes，to textual research some important place names. in Tibetan central region，there were four main channels，there are also a number of branch routes. The central government of the Qing Dynasty also set up frontier inspection on these roads，which was also an important measure of the Qing government to exercise state sovereignty in the border areas.