The Outline of the Development Plan for the Guangdong-Hong Kong-Macao Greater Bay Area proposes to build the Bay Area into an international science and technology innovation center with global influence. Among them，improving and strengthening the infrastructure construction in the field of science and technology has become the primary task for the Guangdong-Hong Kong-Macao Greater Bay Area to build an international science and technology innovation center. At present，the Guangdong-Hong Kong-Macao Greater Bay Area has achieved certain results in the construction of scientific and technological infrastructure with the advantages of solid economic foundation，accelerated accumulation of talents and policy superposition. However，the problems such as lack of overall planning，insufficient synergy effect，weak discipline support in related fields and lack of high-end personnel are particularly prominent. In view of the above shortcomings，the report points out that the Guangdong-Hong Kong-Macao Greater Bay Area can be overcome by a series of measures，such as building four major facilities clusters，increasing the investment in basic research，and building a research-oriented university talent training support system.