This report focuses on the analysis of “industrial chain safety issues in Guangdong-Hong Kong-Macao Greater Bay Area”，focusing on the industrial chain safety issues of five key industries：new-generation electronic information，green petrochemical，biomedical and health，smart home appliances and new energy vehicles. Contrast report based on the international comparison，provinces and cities such as comparison，subdivision industry，industrial relevance analysis perspective，based on a large bay area of guangdong five industrial chain，analyzes its development situation of the industrial chain to explore the safe development of the industry chain of “free point”，and put forward corresponding counter-measures and Suggestions on the basis of this，in response to the economic situation changes and outbreak exogenous shocks，such as It will provide feasible solutions for the restructuring of the global governance system and industrial chain after the pandemic，prevent overreaction，and promote the construction of industrial chains and supply chains with more innovation，higher added value，safety，reliability，green and low-carbon in a prudent and orderly manner，so as to realize the independent，controllable，safe and stable development of industrial chains at a high level.