The development and growth of China’s manufacturing industry has benefited from its active participation in the global division of labor. However，as slow globalization marked by regionalization has gradually become an important feature of globalization，the development prospects of China’s manufacturing industry have become the focus of attention. In fact，after entering the 21st century，with the improvement of China’s manufacturing technology level，the ability of China’s manufacturing industry to shape its own development environment has become increasingly stronger. In this process，China’s manufacturing industry has shown obvious characteristics of “global sales and regional production”. Therefore，the strengthening of regionalization trend in globalization will not fundamentally shake the foundation of China’s manufacturing industry. China should promote the construction of regional economic cooperation mechanisms at different levels of the East Asian regional production network，accelerate the implementation of the dual-circulation strategy，tap the potential of the domestic consumption market，consolidate the existing division of labor between China and the East Asian regional production network，and seek to improve the East Asian regional security mechanism. Prevent the “political spillover” of sudden security incidents from undermining the economic division of labor between China and East Asian countries.