Based on the provincial panel data from 2013 to 2020，this report examines the influence of the development digital economy on the development quality of Guangdong’s manufacturing industry and its influence channels. The principal component analysis method is used to construct indicator systems for the development level of the digital economy and the manufacturing quality. The research finds that：First，the development of the digital economy significantly promotes the manufacturing development quality in China. On average，if the development level of the digital economy increases by 1%，the manufacturing development quality will increase by 0.461%. Meanwhile，compared with other provinces，the development of the digital economy in Guangdong has a stronger role in promoting manufacturing development quality. Second，as influence channels，the development of digital economy improves the manufacturing development quality mainly by optimizing the manufacturing structure，promoting the innovation-driven and green development manufacturing industry. However，the development of digital economy does not play a significant role in improving the economic efficiency of manufacturing industry. Third，compared with the western region，the digital economy development in the eastern and central provinces of China plays a greater role in optimizing the manufacturing structure and promoting green development，and there is no significant difference between the development quality and the economic efficiency of manufacturing industry. Fourth，Guangdong’s manufacturing development quality is generally at the leading level in China，especially in terms of innovation-driven，but the advantages are not prominent in other sub-indices of manufacturing development quality.