2019 is the beginning of the development of cultural tourism integration，but also the key year of its high-quality development. In 2020，COVID spread to the world. Affected by the epidemic the national cultural tourism industry has been stopped，and cultural tourism enterprises at Guangdong-Hong Kong-Macau Greater Bay Area face huge survival pressure due to the global passenger mobility decline. The cultural tourism industry can seize the opportunity and turn the crisis into an opportunity to speed up the transformation and upgrading，advance the high-quality development and help the domestic economy to recover its vitality. The supply-side structural reform of Guangdong-Hong Kong-Macau Greater Bay Area is imperative. It is necessary to optimize the industrial ecosystem，gather dynamic innovation and development elements，and give full play to the main role of enterprises，so as to promote the development of cultural tourism industry of Guangdong-Hong Kong-Macau Greater Bay Area to high quality. We believe that it is necessary to give Zhuhai full play to the advantages of the core cities in the west bank of Pearl River and the important portal hub of Greater Bay Area，to lead the deep integration of cultural tourism products at Guangdong-Hong Kong-Macau Greater Bay Area；to give full play to the emerging scientific and technological advantages and to improve the construction of intelligent cultural tourism platform；to set up incentive mechanism for cultural tourism industry and to stabilize the main body of cultural tourism market；to promote the transformation and upgrading of the cultural tourism industry through fine service and fine management；to fully integrate into the construction of traffic integration in Greater Bay Area，and provide convenient transportation conditions for the cultural tourism industry.