Guangzhou Thirteen Hong was the birthplace of the ancient Maritime Silk Road and played an extremely important role in the modern history of trade exchanges with foreign countries. How to excavate and protect Thirteen Hongs commercial cultural sites and establish cultural brand？According to preliminary study from the perspective of local culture development in Liwan District，Guangzhou should take Thirteen Hongs cultural sites as the core to establish “World’s Commercial and Cultural Street” and create ecosystem museums tourism routs. Besides，the landmarks should be reconstructed，as well as the promotion of Thirteen Hongs brand names to polish the “21^st Century Maritime Silk Road” cultural brand.