Zhuhai is not only one of the first cities to have reform and opening up in China but also the important connection point of the ancient and modern “maritime Silk Road”. The micro strategy of incorporating Zhuhai Harbor development into “One belt，one road” construction is a major strategic requirement for Zhuhai to realize economic and social development by leaps and bounds as well as to realize new breakthroughs in institutional innovation，thus promoting economic structure adjustment and upgrading. The strategy has certain advantages as well as problems and bottlenecks. The main policies we put forward include：promoting cooperation between China and Portugal in the establishment of “Sino-Portuguese Institute” to expand the channels for policy communication；promoting the establishment of “infrastructure industry，high-tech and service transfer base”；promoting the establishment of “China and Latin America，the South Asian port city alliance”；promoting cultural exchange integration relying on the exhibition industry and other characteristics industries.