In the history of mankind，the 15^th to the 18^th centuries was a period of great changes. As the Europeans started the Age of Discovery or the Age of Exploration，a new era of global maritime trade came along. And the development of the Age of Exploration brought the first wave of trade globalization. Back then，trade among different areas was in a structure of point-to-point connections. Before the 18^th century，the connotation and function of culture/product trade mediators were far different from that of nowadays. Although “cultural mediators” now are not involved in the process of cultural creation，they do need to convey specific culture from one area to another in different ways. Can modern cultural agents fulfill the role of cultural mediators？And besides individuals and organizations involved in trading and exchanges，who can serve as cultural mediators on the 21^st-century Maritime Silk Road and help building its trade structure？In view of the “Belt and Road（B&R）” initiative，these are the problems to be understood and solved by the cultural and creative industries（CCI）in Macao，China，Asia and all the other parts of the world.