Brexit has great influence on Britain and the EU，and it is also linked with Japan，which has close ties with both Britain and the EU. For a long time，Britain has been the gateway for Japan to connect with the EU，and it has impact on all aspects of Japan’s cooperation with Europe. Brexit forces Japan to reconsider and redefine its relationship with Britain and the EU. Brexit has promoted Japan，the EU and Britain to participate more actively in international affairs. Japan has strengthened cooperation with the EU and Britain at the same time. Japan and the EU signed the EPA and the SPA to continuously enhance economic，political and security ties. Japan and Britain have also actively strengthened political and security cooperation. After the signing of the Japan-EU EPA，Japan and Britain have also rapidly finished negotiations on the EPA. Japan and Europe have entered a stage of comprehensive and strategic cooperation.