The worldwide spread of the COVID-19 epidemic has drastically changed the basic ways of exchanges among individuals，societies and countries. In terms of the people-to-people exchanges between China and Japan，there has been frustration as well as emergence of new trends featuring mutual assistance，new ways of communication，growing focus on medical and health-care service and stronger motivation for regional exchanges. China-Japan people-to-people exchanges has been efficient in promoting mutual understanding between two peoples，but it is also influenced by the national sentiments of both sides. Both China and Japan are responsible to reflect on the issue and find a solution. China-Japan people-to-people exchanges may recovery after the end of the COVID-19 epidemic，however，Japan’s anxiety over its strength and position will still serve as an important factor in China-Japan relation，and there will be also some negative factor for China-Japan people-to-people exchanges.