With Sino-U.S. relations entering the phase of strategic competition，the U.S government has begun to adjust its foreign economic strategy in order to maintain its world hegemony. The Indo-Pacific Strategy，launched during the Trump administration，aims to strengthen ties with Allies and partners across a range of political，economic and security fronts and address the challenge to its interests posed by the rise of China by building a “free and open Indo-Pacific region”. The Indo-Pacific strategy has had an impact on the progress of the Regional Comprehensive Economic Partnership （RCEP） n the area of trade and investment. On the trade dimension，the regression model demonstrates that the increase of U.S. trade with RCEP countries will not lead to a reduction of Chinese trade with those countries. U.S. exports of technology-intensive goods will elevate the competition with China in the same industries，but China is able to maintain trade stability through exporting labor-intensive goods，thus alleviate the “zero-sum competition”. Regarding investment，since U.S. foreign direct investment are concentrated in service industries，it contributes to the growth of domestic industries in the host country；meanwhile，Chinese investment in the fields of manufacturing lead to a “crowding-out effect” on local industries in the short term，which will have a negative impact on the further development of investment relations between Chinese enterprises and RCEP member states. Encountering U.S. economic competition，China should continue to enhance scientific and technological innovation，so as to upgrade the quality of products and diversify trade composition. It is also critical for Chinese companies to integrate their investment projects with the interests of local industries and communities. This will lay a solid foundation for the development of investment relationships between China and RCEP countries.