The Guangdong-Hong Kong-Macao Greater Bay Area is the leader of China’s reform and opening up，the construction of global influence international science and technology innovation center is the top priority. At present，the Guangdong-Hong Kong-Macao Greater Bay Area has achieved remarkable results in the initial stage of its construction as an international science and a technology innovation center. This research system summarizes the major measures taken by the Greater Bay Area in “Guangzhou-Shenzhen-Hong Kong-Macao” since 2019 and the outstanding results achieved，such as the construction of science and technology innovation corridors，the construction of major science and technology infrastructure and innovation platforms，policy innovation，and industry Technology empowers，trains and attracts talents，etc. This research also analyzes the challenges and main problems faced by the five aspects of basic research，talents，innovation industry clusters，work system and synergy，and collaborative innovation systems and mechanisms. Finally，from five aspects，during the “14th Five-Year Plan” period，the Guangdong-Hong Kong-Macao Greater Bay Area adheres to the support and guidance of scientific and technological innovation and strives to become a pioneer in the country’s innovation-driven high-quality development. These five aspects include continuing to promote the coordinated development of high-quality innovation，promoting basic research and applied basic research to make breakthroughs first，building an independent and controllable modern industrial system，creating a new highland for international talents，and strengthening theoretical exploration.