The development of the Guangdong-Hong Kong-Macao Greater Bay Area has been raised into the national strategy. The civil aviation industry is the basic，strategic and leading industry. The advancing of the coordinated development of airport cluster in the Guangdong-Hong Kong-Macao Greater Bay Area is the strategic underpinning for promoting the development of the world-class city cluster. To promote the construction of the Greater Bay Area requires sizing-up the situation，seizing the opportunities，overcoming the difficulties and challenges to accelerate the establishment of coordinated development of the airport cluster，the construction of interconnection system of the airport cluster，the optimization of the allocation and layout of the airports，the design of the overall and integrated airport economy，and the achievement of the docking of the management system.