The death of Venezuelan President Hugo Chavez aroused worldwide conjecture about the future trend of the country's political situation, foreign policy orientation, even the fate of the left-wing movement and integration process in Latin America. Regardless of the result of the forthcoming general election, Venezuela will experience a long-time political transition period. Subject to the constraints of national interests, the status quo of economic and social development, political parties in the "the post-Chavez era" will need to adjust its domestic and international strategies and priorities. Therefore, its domestic policy adjustment is bound to be limited and moderate. The diversified pattern of opening up to the outside world will probably remain. However, in terms of its policy on the United States, ALBA (Alianza Bolivariana para los Pueblos de Nuestra América / Tratado de Comercio de los Pueblos), as well as the Caribbean Petroleum Plans, once the opposition party is in office, it is likely to have an "overdone". Sino-Venezuelan cooperation is in line with the major development interests of both sides. It is built on a mutual beneficial and win-win basis with a new partnership model beyond ideology. No matter how political situation changes, the bilateral relations are unlikely to be reversed fundamentally. China should grasp and recognize the domestic political development, improve the working mechanism of policy coordination and risk management, as well as further enhance its adaptability, initiative and foresight in dealing with Venezuelan issues in the future.