Changes in the economic，political，and social fields will reshape Latin American Foreign Relations，the region needs to cope with multiple impacts brought by external systemic adjustment and multiple challenges brought by internal changes at the same time. The geopolitical pattern in Latin America，especially in South America，is being reversed，major adjustments have been made to the foreign policies of regional powers，the regional ideology is diverse and even polarized，which intensifies the confrontation between the left and right governments，and has an impact on regional solidarity，leading to increased geopolitical risks and a new differentiated combination of regional cooperation agendas. The United States has continued to increase its involvement in Latin American affairs，it has frequently pressed immigration and trade issues under the “U.S. Priority” strategy，and has stepped up the efforts of the right-wing government to suppress the left-wing government and stepped up its rejection of major powers outside the region. Latin American countries are facing more pressure on autonomous diplomacy. With the promotion of cross regional cooperation，economy and trade remain important concerns. China-Latin America relations have stabilized in a changing situation and are showing a new trend of development，the new country-specific differences emerge in China-Latin America trade，diversity and institutionalization of economic and trade cooperation have been further improved. In 2020，we need to pay attention to the impact of the COVID-19 pandemic，the political situation of some countries，and the US general election on the international relations in Latin America.