Thirteen five period is the key period for Jilin economy to realize the strategic upgrading and transformation of development. The in Jilin Province Science and technology innovation practice based, analysis of the problem, sum up experience proposed in 45 period five initiatives to support promoting scientific and technological innovation, building an innovation of Jilin implementation path, which is to deepen the reform of system of science and technology, enhance the dominant position of enterprises, accelerate the transformation of scientific and technological achievements, continue to strengthen personnel support, and vigorously promote the management innovation. This paper describes the basic theory and practice of scientific and technological innovation. Secondly, science and technology innovation capability of Jilin Province were present situation analysis, then to 2014, Jilin Province, promote scientific and technological innovation is an important measure were reviewed, finally, to clarify the 45 during promote scientific and technological innovation, construction of the innovation of Jilin the concrete realization of the path.