This paper analyzes the Kharosthi Inscription Coins，and draws the following conclusions，the Kharosthi Inscription Coins was originated in the first half of the 2nd century BC，almost stopped in the early of 2nd century AD，and ultimately stopped in the end of 3rd century AD. The circulation and spreading regions contained Northwest India，Bactria and Tarim Basin. Those minters and users contained Greek，Scythian，Parthian，Indian，Kushan and Khotan.